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OpenAI and Los Alamos National Laboratory announce a partnership to evaluate how multimodal AI models can be used safely by scientists in laboratory settings

Evan Gorelick / Bloomberg :

Bloomberg Evan Gorelick

Context & Ripple Effects

This collaboration sits early in a broader arc of OpenAI working with public-sector research and safety institutions. It was followed by plans for US national laboratories to use o1 models, including work to deploy a model on Los Alamos' Venado supercomputer expanding model use at Los Alamos.

The partnership also foreshadowed more formal external scrutiny: OpenAI and Anthropic later agreed to provide the US AI Safety Institute early access to major models early-access government evaluations, while OpenAI later flagged elevated biosecurity concerns in upcoming models higher-risk model capabilities.

First-order effects

  • Los Alamos gains a direct role in testing how multimodal models behave in scientific laboratory workflows, rather than assessing their safety solely through general-purpose benchmarks.
  • OpenAI gains domain-specific feedback on laboratory use cases and risks, giving its safety work an institutional research setting.

Second-order effects

  • The collaboration creates a practical reference point for other AI developers and research labs considering whether multimodal systems need specialist evaluation before scientific deployment.
  • It strengthens the case for safety testing to track the contexts in which models are used—especially where scientific assistance can carry dual-use implications—rather than treating model capability as a standalone question.

Third-order effects

  • If such partnerships become routine, access to advanced models for sensitive research may increasingly be paired with evaluations run by national laboratories or government-linked institutions.
  • The longer-term shift is toward AI labs building strategic legitimacy through externally credible safety processes, though this single partnership does not establish a universal deployment standard.

The trend: Frontier AI providers are tying scientific access to increasingly formal, domain-specific safety evaluation with public research institutions.

Discussion

  • @andrewcurran_ Andrew Curran on x
    OpenAI and Los Alamos National Laboratory have formed a partnership to study model bioscience capabilities. Los Alamos has also established AIRTAG the AI Risks and Threat Assessments Group. GPT-4o, with Voice Mode enabled, will be used in lab to assist bioresearch. [image]
  • @gdb Greg Brockman on x
    OpenAI for bioscience:
  • @ethancaballero @ethancaballero on x
    Manhattan Project announces partnership with Manhattan Project.
  • @tejalpatwardhan Tejal Patwardhan on x
    latest from preparedness: we're developing wet lab biology evals with @LosAlamosNatLab and @nickgenerous keen to learn how gpt-4o's vision and voice capabilities can assist scientists with real-world lab tasks (e.g., troubleshooting cell culture growth)
  • r/OpenAI r on reddit
    OpenAI and Los Alamos National Laboratory Work Together on Frontier Model Safety