Discussion

• @ylecun Yann LeCun on x

  https://evolutionaryscale.ai/ : an AI-for-proteomics startup that just came out of stealth. They are announcing ESM3 a 98B-paramter generative LLM for “programming biology.” Using ESM3 and a simulated evolutionary process, they have produced a new type GFP (Green Fluorescent Prot…

• @natfriedman Nat Friedman on x

  Evolutionary Scale comes out of stealth and announces ESM3, the largest protein language model trained to date, and demonstrates using it to discover a new fluorescent protein. “From the rate of diversification of GFPs found in nature, we estimate that this generation of a new

• @pdhsu Patrick Hsu on x

  Delighted to co-lead the $142M seed round in EvolutionaryScale with @natfriedman @danielgross @Lux_Capital, a new frontier AI lab that has now trained ESM3, a natively multimodal and generative language model for proteins and the largest biological language model to date

• @alexrives Alex Rives on x

  We have trained ESM3 and we're excited to introduce EvolutionaryScale. ESM3 is a generative language model for programming biology. In experiments, we found ESM3 can simulate 500M years of evolution to generate new fluorescent proteins. Read more: https://www.evolutionaryscale.ai…

• @moalquraishi Mohammed AlQuraishi on x

  ESM3 is out from EvolutionaryScale! 98B params (~GPT3 scale). Multimodal over sequence, structure, and function with cool design applications. Trained on variable masking ratios and decodes proteins iteratively. Some work on alignment too. Looks exciting! https://www.evolutionary…